In Vivo Antiplasmodial Activity of Detarium microcarpum (Fabaceae) Stem Bark Extract

Background: Malaria is a parasitic infection that common in the tropical and sub-tropical regions of world. It estimated to kill one million individuals annually. Detarium microcarpum (Fabaceae family) used traditionally for treatment malaria, diabetes, hypertension, convulsions, pneumonia, leprosy, meningitis. The purpose this research was evaluate antiplasmodial potential safety profile methanol extract D. stem bark. Methods: subjected phytochemical screening oral median lethal dose (LD50) estimation. Using curative, suppressive, prophylactic experimental animal models, activity assessed mice infected with chloroquine-sensitive Plasmodium berghei berghei. Biochemical hematological tests were conducted rats orally administered 28 days. One-way analysis variance (ANOVA) analyze data, followed by Dunnett's post hoc test. Results: Alkaloids, flavonoids, saponins, tannins, triterpenes, glycosides found through analysis. When compared negative control group, at tested doses (200, 400, 800 mg/kg) showed significant (P < 0.001) effect significantly prolonged survival time treated groups. had an insignificant > 0.05) on biochemical parameters tested. Conclusion: results suggest bark possesses relatively safe after short-term use.